LGALS8 anticorps (Internal Region)

N° du produit ABIN6262956

Détail du produit anti-LGALS8 anticorps

Antigène: LGALS8 (Lectin, Galactoside-Binding, Soluble, 8 (LGALS8))

Épitope: Internal Region

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LGALS8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: Galectin 8 Antibody detects endogenous levels of total Galectin 8.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Galectin 8, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur LGALS8

Antigène: LGALS8 (Lectin, Galactoside-Binding, Soluble, 8 (LGALS8))

Autre désignation: LGALS8 (LGALS8 Produits)

Synonymes: anticorps LGALS8, anticorps 1200015E08Rik, anticorps AI326142, anticorps D13Ertd524e, anticorps Lgals-8, anticorps galectin-8, anticorps Gal-8, anticorps PCTA-1, anticorps PCTA1, anticorps Po66-CBP, anticorps xgalectin-VIIIa, anticorps galectin 8, anticorps lectin, galactose binding, soluble 8, anticorps lectin, galactoside binding soluble 8 S homeolog, anticorps LGALS8, anticorps Lgals8, anticorps lgals8.S

Sujet:

Description: Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane, these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902).

Gene: LGALS8

Poids moléculaire: 40 kDa

ID gène: 3964

UniProt: O00214