LIG4 anticorps (C-Term)

N° du produit ABIN6262967

Détail du produit anti-LIG4 anticorps

Antigène: LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LIG4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: DNA Ligase IV Antibody detects endogenous levels of total DNA Ligase IV.

Homologie: Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human DNA Ligase IV, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur LIG4

Antigène: LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))

Autre désignation: LIG4 (LIG4 Produits)

Synonymes: anticorps zgc:165595, anticorps lig4, anticorps DNA LIGASE IV, anticorps LIG4, anticorps lig4-A, anticorps 5830471N16Rik, anticorps tiny, anticorps DNL4, anticorps ligase IV, DNA, ATP-dependent, anticorps DNA ligase 4, anticorps ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining, anticorps DNA ligase IV, anticorps ligase IV, DNA, ATP-dependent L homeolog, anticorps lig4, anticorps LIG4, anticorps LOC100212302, anticorps CpipJ_CPIJ005161, anticorps PTRG_09982, anticorps MCYG_05151, anticorps LOC657210, anticorps ATLIG4, anticorps lig4.L, anticorps Lig4

Sujet:

Description: Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Gene: LIG4

Poids moléculaire: 104kDa

ID gène: 3981

UniProt: P49917

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response