NDC80 anticorps (C-Term)

N° du produit ABIN6263548

Détail du produit anti-NDC80 anticorps

Antigène: NDC80 (NDC80 Kinetochore Complex Component Homolog (NDC80))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NDC80 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: NDC80 Antibody detects endogenous levels of total NDC80.

Homologie: Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human NDC80, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur NDC80

Antigène: NDC80 (NDC80 Kinetochore Complex Component Homolog (NDC80))

Autre désignation: NDC80 (NDC80 Produits)

Synonymes: anticorps CG9938, anticorps Dmel\\CG9938, anticorps Hec1, anticorps NDC80, anticorps dNdc80, anticorps dmNdc80, anticorps hec1, anticorps KNTC2, anticorps ndc10, anticorps tid3, anticorps 2610020P18Rik, anticorps AV139730, anticorps HEC, anticorps HEC1, anticorps Kntc2, anticorps kntc2l, anticorps wu:fb52e02, anticorps zgc:111801, anticorps HsHec1, anticorps TID3, anticorps hsNDC80, anticorps kntc2, anticorps NDC80, kinetochore complex component, anticorps CG9938 gene product from transcript CG9938-RA, anticorps spindle pole body protein Ndc80, anticorps kinetochore protein Ndc80, anticorps NDC80 homolog, kinetochore complex component (S. cerevisiae), anticorps NDC80 kinetochore complex component, anticorps NDC80 kinetochore complex component S homeolog, anticorps NDC80, anticorps Ndc80, anticorps ndc80, anticorps ndc80.S

Sujet:

Description: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:9315664, PubMed:12351790, PubMed:14654001, PubMed:14699129, PubMed:15062103, PubMed:15235793, PubMed:15239953, PubMed:15548592, PubMed:16732327). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:15548592). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules (PubMed:25743205, PubMed:23891108).

Gene: NDC80

Poids moléculaire: 74kDa

ID gène: 10403

UniProt: O14777

Pathways: Maintenance of Protein Location