Reticulon 4 anticorps (Internal Region)

N° du produit ABIN6263682

Détail du produit anti-Reticulon 4 anticorps

Antigène: Reticulon 4 (RTN4)

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Reticulon 4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: Nogo A Antibody detects endogenous levels of total Nogo A.

Homologie: Pig,Horse,Rabbit

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human Nogo A, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:50-200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Reticulon 4

Antigène: Reticulon 4 (RTN4)

Autre désignation: RTN4 (RTN4 Produits)

Synonymes: anticorps ASY, anticorps NI220/250, anticorps NOGO, anticorps NOGO-A, anticorps NOGOC, anticorps NSP, anticorps NSP-CL, anticorps Nbla00271, anticorps Nbla10545, anticorps Nogo-B, anticorps Nogo-C, anticorps RTN-X, anticorps RTN4-A, anticorps RTN4-B1, anticorps RTN4-B2, anticorps RTN4-C, anticorps RTN4-Cw, anticorps DKFZp459C0314, anticorps 1110020G17Rik, anticorps AA407876, anticorps AA409940, anticorps AA960376, anticorps C130026I10Rik, anticorps NgA, anticorps Nogo-A, anticorps mKIAA0886, anticorps mKIAA4153, anticorps NI-250, anticorps Nogo, anticorps Vp20, anticorps r, anticorps rat N, anticorps rat NogoA, anticorps reticulon-4, anticorps nogo, anticorps rtn4, anticorps wu:fb17a02, anticorps wu:fb22f12, anticorps wu:fd61a07, anticorps zgc:92163, anticorps reticulon 4, anticorps reticulon 4a, anticorps RTN4, anticorps rtn4, anticorps Rtn4, anticorps rtn4a

Sujet:

Description: Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex (By similarity). Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. Induces the formation and stabilization of endoplasmic reticulum (ER) tubules (PubMed:25612671, PubMed:24262037, PubMed:27619977). Regulates membrane morphogenesis in the ER by promoting tubular ER production (PubMed:27619977). Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).

Gene: RTN4

Poids moléculaire: 129 kDa

ID gène: 57142

UniProt: Q9NQC3

Pathways: Neurotrophin Signaling Pathway, Regulation of Cell Size, SARS-CoV-2 Protein Interactome