PHF19 anticorps (Internal Region)

N° du produit ABIN6264174

Détail du produit anti-PHF19 anticorps

Antigène: PHF19 (PHD Finger Protein 19 (PHF19))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PHF19 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: PHF19 Antibody detects endogenous levels of total PHF19.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PHF19, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur PHF19

Antigène: PHF19 (PHD Finger Protein 19 (PHF19))

Autre désignation: PHF19 (PHF19 Produits)

Synonymes: anticorps si:dkeyp-51b7.1, anticorps pcl3, anticorps MGC147603, anticorps MTF2L1, anticorps PCL3, anticorps TDRD19B, anticorps 3110009G19Rik, anticorps 3321402G02Rik, anticorps PHD finger protein 19, anticorps Phf19, anticorps PHF19, anticorps phf19

Sujet:

Description: Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing. Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds dimethylated at 'Lys-36' (H3K36me2). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter.

Gene: PHF19

Poids moléculaire: 66 kDa

ID gène: 26147

UniProt: Q5T6S3

Pathways: Stem Cell Maintenance