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PIK3CA anticorps (Internal Region)

PIK3CA Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6264190
  • Antigène Voir toutes PIK3CA Anticorps
    PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))
    Épitope
    • 15
    • 15
    • 13
    • 11
    • 9
    • 7
    • 7
    • 7
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 88
    • 60
    • 32
    • 25
    • 15
    • 3
    • 2
    Humain, Souris, Rat
    Hôte
    • 88
    • 8
    • 2
    • 1
    Lapin
    Clonalité
    • 84
    • 15
    Polyclonal
    Conjugué
    • 33
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PIK3CA est non-conjugé
    Application
    • 78
    • 38
    • 32
    • 26
    • 26
    • 12
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    PI3 kinase P110 alpha Antibody detects endogenous levels of total PI3 kinase P110 alpha.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human PI3 kinase P110 alpha, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PIK3CA Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))
    Autre désignation
    PIK3CA (PIK3CA Produits)
    Synonymes
    anticorps CLOVE, anticorps CWS5, anticorps MCAP, anticorps MCM, anticorps MCMTC, anticorps PI3K, anticorps p110-alpha, anticorps C-P3K, anticorps PI3-kinase, anticorps PI3K-alpha, anticorps pi3-k, anticorps pi3k, anticorps AA414921, anticorps C530050K14, anticorps p50alpha, anticorps p55alpha, anticorps p85alpha, anticorps 6330412C24Rik, anticorps caPI3K, anticorps p110, anticorps p110alpha, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, anticorps Phosphoinositide-3-kinase, catalytic, alpha polypeptide, anticorps phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha, anticorps phosphoinositide-3-kinase regulatory subunit 1, anticorps PIK3CA, anticorps GL50803_14855, anticorps pik3ca, anticorps Pik3ca, anticorps Pik3r1
    Sujet

    Description: Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation through the PDPK1-AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Also has serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS. Plays a role in the positive regulation of phagocytosis and pinocytosis (By similarity).

    Gene: PIK3CA

    Poids moléculaire
    124 kDa
    ID gène
    5290
    UniProt
    P42336
    Pathways
    Signalisation PI3K-Akt, Signalisation RTK, TCR Signaling, AMPK Signaling, Interferon-gamma Pathway, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, VEGF Signaling
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