PITX3 anticorps

N° du produit ABIN6264234

Détail du produit anti-PITX3 anticorps

Antigène: PITX3 (Pituitary Homeobox 3 (PITX3))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PITX3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: PITX3 Antibody detects endogenous levels of total PITX3

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human PITX3

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000 IHC 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur PITX3

Antigène: PITX3 (Pituitary Homeobox 3 (PITX3))

Autre désignation: PITX3 (PITX3 Produits)

Synonymes: anticorps CTPP4, anticorps CTRCT11, anticorps PTX3, anticorps pitx3, anticorps Ptx3, anticorps ak, anticorps zgc:109716, anticorps pitx3-A, anticorps xPitx3, anticorps paired like homeodomain 3, anticorps paired-like homeodomain 3, anticorps paired like homeodomain 3 L homeolog, anticorps paired-like homeodomain transcription factor 3, anticorps paired-like homeodomain transcription factor Pitx3, anticorps PITX3, anticorps Pitx3, anticorps pitx3.L, anticorps pitx3

Sujet:

Description: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins. Positively regulates FOXE3 expression and negatively regulates PROX1 in the anterior lens epithelium, preventing activation of CDKN1B/P27Kip1 and CDKN1C/P57Kip2 and thus maintains lens epithelial cells in cell cycle (By similarity).

Gene: PITX3

Poids moléculaire: 32 kDa

ID gène: 5309

UniProt: O75364