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PRKRA anticorps (Internal Region)

PRKRA Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6264430
  • Antigène Voir toutes PRKRA Anticorps
    PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))
    Épitope
    • 10
    • 8
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 52
    • 15
    • 14
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 45
    • 8
    Lapin
    Clonalité
    • 46
    • 6
    Polyclonal
    Conjugué
    • 32
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PRKRA est non-conjugé
    Application
    • 31
    • 24
    • 17
    • 8
    • 7
    • 4
    • 3
    • 3
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    PRKRA Antibody detects endogenous levels of total PRKRA.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human PRKRA, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product PRKRA Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))
    Autre désignation
    PRKRA (PRKRA Produits)
    Synonymes
    anticorps PRKRA, anticorps AV120107, anticorps PRK, anticorps Pact, anticorps RAX, anticorps lear, anticorps DYT16, anticorps PACT, anticorps im:7151758, anticorps zgc:162619, anticorps dyt16, anticorps pact, anticorps prkra-a, anticorps prkra-b, anticorps rax, anticorps rbpa, anticorps protein activator of interferon induced protein kinase EIF2AK2, anticorps protein kinase, interferon inducible double stranded RNA dependent activator, anticorps protein kinase, interferon-inducible double stranded RNA dependent activator, anticorps protein activator of interferon induced protein kinase EIF2AK2 L homeolog, anticorps PRKRA, anticorps Prkra, anticorps prkra, anticorps prkra.L
    Sujet

    Description: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).

    Gene: PRKRA

    Poids moléculaire
    34kDa
    ID gène
    8575
    UniProt
    O75569
    Pathways
    Regulatory RNA Pathways
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