PRKRA anticorps (Internal Region)
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- Antigène Voir toutes PRKRA Anticorps
- PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp PRKRA est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- PRKRA Antibody detects endogenous levels of total PRKRA.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human PRKRA, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product PRKRA Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- PRKRA (Protein Kinase, Interferon-Inducible Double Stranded RNA Dependent Activator (PRKRA))
- Autre désignation
- PRKRA (PRKRA Produits)
- Synonymes
- anticorps PRKRA, anticorps AV120107, anticorps PRK, anticorps Pact, anticorps RAX, anticorps lear, anticorps DYT16, anticorps PACT, anticorps im:7151758, anticorps zgc:162619, anticorps dyt16, anticorps pact, anticorps prkra-a, anticorps prkra-b, anticorps rax, anticorps rbpa, anticorps protein activator of interferon induced protein kinase EIF2AK2, anticorps protein kinase, interferon inducible double stranded RNA dependent activator, anticorps protein kinase, interferon-inducible double stranded RNA dependent activator, anticorps protein activator of interferon induced protein kinase EIF2AK2 L homeolog, anticorps PRKRA, anticorps Prkra, anticorps prkra, anticorps prkra.L
- Sujet
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Description: Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at 'Lys-386' at 'Ser-392' respectively and enhances its activity in a EIF2AK2/PKR-dependent manner (By similarity).
Gene: PRKRA
- Poids moléculaire
- 34kDa
- ID gène
- 8575
- UniProt
- O75569
- Pathways
- Regulatory RNA Pathways
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