SRSF1 anticorps

N° du produit ABIN6265029

Détail du produit anti-SRSF1 anticorps

Antigène: SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SRSF1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: SFRS1 Antibody detects endogenous levels of total SFRS1

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SFRS1

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur SRSF1

Antigène: SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Autre désignation: SFRS1 (SRSF1 Produits)

Synonymes: anticorps ASF, anticorps SF2, anticorps SF2p33, anticorps SFRS1, anticorps SRp30a, anticorps 1110054N12Rik, anticorps 5730507C05Rik, anticorps 6330415C05Rik, anticorps AI482334, anticorps AW491331, anticorps Asf, anticorps Sf2, anticorps Sfrs1, anticorps DKFZp469K2419, anticorps sfrs1, anticorps sfrs1b, anticorps wu:fb80g05, anticorps zgc:111894, anticorps zgc:65898, anticorps zgc:76897, anticorps asf, anticorps sf2, anticorps sf2p33, anticorps srp30a, anticorps sfrs1a, anticorps sfrs1l, anticorps wu:fb52g10, anticorps wu:fb97g12, anticorps zgc:66146, anticorps serine and arginine rich splicing factor 1, anticorps serine/arginine-rich splicing factor 1, anticorps serine/arginine-rich splicing factor 1b, anticorps serine/arginine-rich splicing factor 1 L homeolog, anticorps serine/arginine-rich splicing factor 1a, anticorps SRSF1, anticorps Srsf1, anticorps srsf1b, anticorps srsf1.L, anticorps srsf1a

Sujet:

Description: Plays a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Can stimulate binding of U1 snRNP to a 5'-splice site-containing pre-mRNA. Binds to purine-rich RNA sequences, either the octamer, 5'-RGAAGAAC-3' (r=A or G) or the decamers, AGGACAGAGC/AGGACGAAGC. Binds preferentially to the 5'-CGAGGCG-3' motif in vitro. Three copies of the octamer constitute a powerful splicing enhancer in vitro, the ASF/SF2 splicing enhancer (ASE) which can specifically activate ASE-dependent splicing. Isoform ASF-2 and isoform ASF-3 act as splicing repressors. May function as export adapter involved in mRNA nuclear export through the TAP/NXF1 pathway.

Gene: SRSF1

Poids moléculaire: 28kDa

ID gène: 6426

UniProt: Q07955

Pathways: Ribonucleoprotein Complex Subunit Organization