Shugoshin anticorps (N-Term)

N° du produit ABIN6265044

Détail du produit anti-Shugoshin anticorps

Antigène: Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Shugoshin est non-conjugé

Application: ELISA, Western Blotting (WB)

Specificité: SGOL1 Antibody detects endogenous levels of total SGOL1.

Homologie: Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SGOL1, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur Shugoshin

Antigène: Shugoshin (SGOL1) (Shugoshin 1 (SGOL1))

Autre désignation: SGO1 (SGOL1 Produits)

Synonymes: anticorps sgo1, anticorps NY-BR-85, anticorps SGO, anticorps Sgo1, anticorps 3300001M08Rik, anticorps C81037, anticorps shugoshin 1, anticorps shugoshin centromeric cohesion 1, anticorps shugoshin 1 L homeolog, anticorps Sgo1, anticorps sgo1, anticorps sgo1.L, anticorps SGO1

Sujet:

Description: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase.

Gene: SGO1

Poids moléculaire: 64kDa

ID gène: 151648

UniProt: Q5FBB7

Pathways: Maintenance of Protein Location