SH2D1A anticorps (Internal Region)

N° du produit ABIN6265049

Détail du produit anti-SH2D1A anticorps

Antigène: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SH2D1A est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: SH2D1A Antibody detects endogenous levels of total SH2D1A.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SH2D1A, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SH2D1A

Antigène: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Autre désignation: SH2D1A (SH2D1A Produits)

Synonymes: anticorps DSHP, anticorps EBVS, anticorps IMD5, anticorps LYP, anticorps MTCP1, anticorps SAP, anticorps SAP/SH2D1A, anticorps XLP, anticorps XLPD, anticorps RGD1562408, anticorps Gm686, anticorps SH2D1A, anticorps SH2 domain containing 1A, anticorps SH2D1A, anticorps Sh2d1a

Sujet:

Description: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3.

Gene: SH2D1A

Poids moléculaire: 14kDa

ID gène: 4068

UniProt: O60880

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process