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SHARPIN anticorps (Internal Region)

SHARPIN Reactivité: Humain, Rat, Souris WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265061
  • Antigène Voir toutes SHARPIN Anticorps
    SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
    Épitope
    • 15
    • 7
    • 6
    • 5
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 45
    • 24
    • 19
    • 2
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 42
    • 3
    Lapin
    Clonalité
    • 44
    • 1
    Polyclonal
    Conjugué
    • 17
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SHARPIN est non-conjugé
    Application
    • 41
    • 18
    • 13
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    SHARPIN Antibody detects endogenous levels of total SHARPIN.
    Homologie
    Pig,Bovine,Horse,Sheep
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human SHARPIN, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SHARPIN Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
    Autre désignation
    SHARPIN (SHARPIN Produits)
    Synonymes
    anticorps 0610041B22Rik, anticorps AW121341, anticorps RBCKL1, anticorps SIPL1, anticorps cpdm, anticorps Conneck1, anticorps SHANK-associated RH domain interacting protein, anticorps SHANK associated RH domain interactor, anticorps SHANK-associated RH domain interactor, anticorps Sharpin, anticorps SHARPIN
    Sujet

    Description: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.

    Gene: SHARPIN

    Poids moléculaire
    40 kDa
    ID gène
    81858
    UniProt
    Q9H0F6
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