SHARPIN anticorps (Internal Region)
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- Antigène Voir toutes SHARPIN Anticorps
- SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
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Épitope
- Internal Region
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Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SHARPIN est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Specificité
- SHARPIN Antibody detects endogenous levels of total SHARPIN.
- Homologie
- Pig,Bovine,Horse,Sheep
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human SHARPIN, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product SHARPIN Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- SHARPIN (SHANK-Associated RH Domain Interacting Protein (SHARPIN))
- Autre désignation
- SHARPIN (SHARPIN Produits)
- Synonymes
- anticorps 0610041B22Rik, anticorps AW121341, anticorps RBCKL1, anticorps SIPL1, anticorps cpdm, anticorps Conneck1, anticorps SHANK-associated RH domain interacting protein, anticorps SHANK associated RH domain interactor, anticorps SHANK-associated RH domain interactor, anticorps Sharpin, anticorps SHARPIN
- Sujet
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Description: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Together with FAM105B/otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis.
Gene: SHARPIN
- Poids moléculaire
- 40 kDa
- ID gène
- 81858
- UniProt
- Q9H0F6
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