SIGMAR1 anticorps (Internal Region)

N° du produit ABIN6265082

Détail du produit anti-SIGMAR1 anticorps

Antigène: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIGMAR1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: SIGMAR1 Antibody detects endogenous levels of total SIGMAR1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SIGMAR1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:50-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur SIGMAR1

Antigène: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Autre désignation: SIGMAR1 (SIGMAR1 Produits)

Synonymes: anticorps ALS16, anticorps OPRS1, anticorps SIG-1R, anticorps SR-BP, anticorps SR-BP1, anticorps SRBP, anticorps sigma1R, anticorps AL024364, anticorps Oprs1, anticorps mSigmaR1, anticorps Sigma1R, anticorps oprs1, anticorps zgc:56378, anticorps sigma non-opioid intracellular receptor 1, anticorps sigma non-opioid intracellular receptor 1 L homeolog, anticorps SIGMAR1, anticorps Sigmar1, anticorps sigmar1.L, anticorps sigmar1

Sujet:

Description: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).

Gene: SIGMAR1

Poids moléculaire: 25kDa

ID gène: 10280

UniProt: Q99720

Pathways: SARS-CoV-2 Protein Interactome