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SNAPIN anticorps (N-Term)

SNAPIN Reactivité: Humain, Souris, Rat WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265206
  • Antigène Voir toutes SNAPIN Anticorps
    SNAPIN (SNAP-Associated Protein (SNAPIN))
    Épitope
    • 15
    • 9
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 33
    • 3
    • 3
    • 1
    Humain, Souris, Rat
    Hôte
    • 25
    • 8
    • 1
    Lapin
    Clonalité
    • 29
    • 5
    Polyclonal
    Conjugué
    • 15
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SNAPIN est non-conjugé
    Application
    • 13
    • 13
    • 12
    • 9
    • 8
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    SNAPIN Antibody detects endogenous levels of total SNAPIN.
    Homologie
    Pig,Bovine,Horse,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human SNAPIN, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SNAPIN Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    SNAPIN (SNAP-Associated Protein (SNAPIN))
    Autre désignation
    SNAPIN (SNAPIN Produits)
    Synonymes
    anticorps SNAPAP, anticorps si:dkey-222b8.2, anticorps SNAPIN, anticorps BLOC1S7, anticorps BLOS7, anticorps 25kDa, anticorps AA407989, anticorps AV026596, anticorps Bloc1s7, anticorps Snap25bp, anticorps Snapap, anticorps SNAP associated protein, anticorps SNAP-associated protein L homeolog, anticorps SNAP-associated protein, anticorps SNAPIN, anticorps snapin.L, anticorps snapin, anticorps Snapin
    Sujet

    Description: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:17182842, PubMed:18167355). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).

    Gene: SNAPIN

    Poids moléculaire
    15-18 kDa
    ID gène
    23557
    UniProt
    O95295
    Pathways
    Synaptic Membrane, Synaptic Vesicle Exocytosis
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