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SUPT4H anticorps (C-Term)

SUPT4H1 Reactivité: Humain, Souris WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265266
  • Antigène Voir toutes SUPT4H (SUPT4H1) Anticorps
    SUPT4H (SUPT4H1) (Suppressor of Ty 4 Homolog 1 (SUPT4H1))
    Épitope
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 18
    • 11
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 13
    • 5
    Lapin
    Clonalité
    • 14
    • 4
    Polyclonal
    Conjugué
    • 11
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SUPT4H est non-conjugé
    Application
    • 10
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificité
    SPT4H Antibody detects endogenous levels of total SPT4H.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human SPT4H, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SUPT4H1 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    SUPT4H (SUPT4H1) (Suppressor of Ty 4 Homolog 1 (SUPT4H1))
    Autre désignation
    SUPT4H1 (SUPT4H1 Produits)
    Synonymes
    anticorps SPT4, anticorps SPT4H, anticorps SUPT4H, anticorps Supt4h2, anticorps AL022777, anticorps Supt4h, anticorps Supt4h1, anticorps Supt4h1a, anticorps 142904_at, anticorps CG12372, anticorps DSIF, anticorps Dmel\\CG12372, anticorps Dspt4, anticorps Spt4, anticorps dDSIF, anticorps dspt4, anticorps l(2)k05316, anticorps DSIF small subunit, anticorps spt4, anticorps zgc:92824, anticorps SPT4 homolog, DSIF elongation factor subunit, anticorps suppressor of Ty 4A, anticorps Transcription elongation factor SPT4, anticorps CG12372 gene product from transcript CG12372-RA, anticorps SPT4 homolog, DSIF elongation factor subunit L homeolog, anticorps transcription elongation factor, anticorps transcription elongation factor complex subunit Spt4, anticorps SUPT4H1, anticorps Supt4h1, anticorps Supt4a, anticorps spt-4, anticorps spt4, anticorps supt4h1.L, anticorps CAALFM_C504630WA, anticorps supt4h1
    Sujet

    Description: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites. DSIF can also positively regulate transcriptional elongation and is required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. DSIF acts to suppress transcriptional pausing in transcripts derived from the HIV-1 LTR and blocks premature release of HIV-1 transcripts at terminator sequences.

    Gene: SUPT4H1

    Poids moléculaire
    13 kDa
    ID gène
    6827
    UniProt
    P63272
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