STT3B anticorps (C-Term)

N° du produit ABIN6265353

Détail du produit anti-STT3B anticorps

Antigène: STT3B (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STT3B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Specificité: STT3B Antibody detects endogenous levels of total STT3B.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human STT3B, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur STT3B

Antigène: STT3B (STT3, Subunit of The Oligosaccharyltransferase Complex, Homolog B (STT3B))

Autre désignation: STT3B (STT3B Produits)

Synonymes: anticorps RGD1311563, anticorps 1300006C19Rik, anticorps Simp, anticorps SIMP, anticorps STT3-B, anticorps STT3B, catalytic subunit of the oligosaccharyltransferase complex, anticorps STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae), anticorps Stt3b, anticorps STT3B

Sujet:

Description: Catalytic subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). STT3B is present in a small subset of OST complexes and mediates both cotranslational and post-translational N-glycosylation of target proteins: STT3B-containing complexes are required for efficient post-translational glycosylation and while they are less competent than STT3A-containing complexes for cotranslational glycosylation, they have the ability to mediate glycosylation of some nascent sites that are not accessible for STT3A. STT3B-containing complexes also act post-translationally and mediate modification of skipped glycosylation sites in unfolded proteins. Plays a role in ER-associated degradation (ERAD) pathway that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins by mediating N-glycosylation of unfolded proteins, which are then recognized by the ERAD pathway and targeted for degradation. Mediates glycosylation of the disease variant AMYL-TTR 'Asp-38' of TTR at 'Asn-118', leading to its degradation.

Gene: STT3B

Poids moléculaire: 94 kDa

ID gène: 201595

UniProt: Q8TCJ2