TAP2 anticorps (Internal Region)
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- Antigène Voir toutes TAP2 Anticorps
- TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))
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Épitope
- Internal Region
- Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TAP2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificité
- TAP2 Antibody detects endogenous levels of total TAP2.
- Homologie
- Pig,Horse,Rabbit,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human TAP2, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product TAP2 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))
- Autre désignation
- TAP2 (TAP2 Produits)
- Synonymes
- anticorps ABC18, anticorps ABCB3, anticorps APT2, anticorps D6S217E, anticorps PSF-2, anticorps PSF2, anticorps RING11, anticorps AI462429, anticorps Abcb3, anticorps Ham-2, anticorps Ham2, anticorps MTP2, anticorps Tap-2, anticorps Y1, anticorps jas, anticorps Cim, anticorps transporter 2, ATP binding cassette subfamily B member, anticorps transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), anticorps TAP2, anticorps Tap2
- Sujet
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Description: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Gene: TAP2
- Poids moléculaire
- 76kDa
- ID gène
- 6891
- UniProt
- Q03519
- Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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