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TET1 anticorps (Internal Region)

TET1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265522
  • Antigène Voir toutes TET1 Anticorps
    TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))
    Épitope
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    Internal Region
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 15
    • 7
    • 1
    Lapin
    Clonalité
    • 14
    • 9
    Polyclonal
    Conjugué
    • 19
    • 2
    • 1
    • 1
    Cet anticorp TET1 est non-conjugé
    Application
    • 17
    • 9
    • 5
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificité
    TET1 Antibody detects endogenous levels of total TET1.
    Homologie
    Pig,Bovine,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human TET1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product TET1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    TET1 (Tet Methylcytosine Dioxygenase 1 (TET1))
    Autre désignation
    TET1 (TET1 Produits)
    Synonymes
    anticorps CXXC6, anticorps LCX, anticorps bA119F7.1, anticorps 2510010B09Rik, anticorps AA517754, anticorps BB001228, anticorps Cxxc6, anticorps D10Ertd17e, anticorps mKIAA1676, anticorps tet methylcytosine dioxygenase 1, anticorps solute carrier family 25 member 16, anticorps TET1, anticorps Tet1, anticorps SLC25A16
    Sujet

    Description: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).

    Gene: TET1

    Poids moléculaire
    235kDa
    ID gène
    80312
    UniProt
    Q8NFU7
    Pathways
    Stem Cell Maintenance, L'effet Warburg
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