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TGFBR1 anticorps (Internal Region)

TGFBR1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265544
  • Antigène Voir toutes TGFBR1 Anticorps
    TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
    Épitope
    • 14
    • 12
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 56
    • 48
    • 23
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 68
    • 3
    • 2
    • 2
    Lapin
    Clonalité
    • 71
    • 4
    Polyclonal
    Conjugué
    • 40
    • 8
    • 6
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TGFBR1 est non-conjugé
    Application
    • 59
    • 46
    • 25
    • 9
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    TGFBR1 Antibody detects endogenous levels of total TGFBR1.
    Homologie
    Pig,Bovine,Sheep,Rabbit,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human TGFBR1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product TGFBR1 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    TGFBR1 (Transforming Growth Factor, beta Receptor 1 (TGFBR1))
    Autre désignation
    TGFBR1 (TGFBR1 Produits)
    Synonymes
    anticorps AAT5, anticorps ACVRLK4, anticorps ALK-5, anticorps ALK5, anticorps LDS1A, anticorps LDS2A, anticorps MSSE, anticorps SKR4, anticorps TGFR-1, anticorps aat5, anticorps acvrlk4, anticorps alk-5, anticorps alk5, anticorps lds1a, anticorps lds2a, anticorps skr4, anticorps tgfr-1, anticorps TGFBR1, anticorps x-trr1, anticorps AU017191, anticorps Alk-5, anticorps TbetaR-I, anticorps TbetaRI, anticorps Alk5, anticorps Skr4, anticorps Tgfr-1, anticorps tbetaR-I, anticorps tgfbr1, anticorps zgc:123263, anticorps transforming growth factor beta receptor 1, anticorps transforming growth factor beta receptor I, anticorps transforming growth factor beta receptor I S homeolog, anticorps transforming growth factor, beta receptor I, anticorps transforming growth factor, beta receptor 1, anticorps transforming growth factor, beta receptor 1 a, anticorps TGFBR1, anticorps tgfbr1, anticorps tgfbr1.S, anticorps Tgfbr1, anticorps tgfbr1a
    Sujet

    Description: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 Molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.

    Gene: TGFBR1

    Poids moléculaire
    56 kDa.
    ID gène
    7046
    UniProt
    P36897
    Pathways
    Growth Factor Binding
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