DR4 anticorps

N° du produit ABIN6265699

Détail du produit anti-DR4 anticorps

Antigène: DR4 (Drought-Repressed 4 Protein (DR4))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DR4 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: TR10A antibody detects endogenous levels of total TR10A

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TR10A

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500~1:3000, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Références pour anticorps anti-DR4 (ABIN6265699)

Luo, Pan, Liu, Yuan, Yan: "Sphingomyelin synthase 2 overexpression promotes cisplatin-induced apoptosis of HepG2 cells." dans: Oncology letters, Vol. 15, Issue 1, pp. 483-488, (2018) (PubMed).

Détails sur DR4

Antigène: DR4 (Drought-Repressed 4 Protein (DR4))

Autre désignation: TR10A (DR4 Produits)

Synonymes: anticorps APO2, anticorps CD261, anticorps DR4, anticorps TRAILR-1, anticorps TRAILR1, anticorps TNF receptor superfamily member 10a, anticorps TNFRSF10A

Sujet:

Description: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

Gene: TNFRSF10A

Poids moléculaire: 50kDa

ID gène: 8797

UniProt: O00220

Pathways: Apoptose, Positive Regulation of Endopeptidase Activity