TRPM8 anticorps

N° du produit ABIN6265758

Détail du produit anti-TRPM8 anticorps

Antigène: TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRPM8 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: TRPM8 Antibody detects endogenous levels of total TRPM8

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human TRPM8

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur TRPM8

Antigène: TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))

Autre désignation: TRPM8 (TRPM8 Produits)

Synonymes: anticorps TRPM8, anticorps trpp8, anticorps ltrpc6, anticorps trpm8b, anticorps LTRPC6, anticorps TRPP8, anticorps CMR1, anticorps LTrpC-6, anticorps Trp-p8, anticorps transient receptor potential cation channel subfamily M member 8, anticorps transient receptor potential cation channel subfamily M member 8b L homeolog, anticorps transient receptor potential cation channel, subfamily M, member 8, anticorps TRPM8, anticorps trpm8b.L, anticorps Trpm8

Sujet:

Description: Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular  pH . Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonist menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing. In prostate cancer cells, shows strong inward rectification and high calcium selectivity in contrast to its behavior in normal cells which is characterized by outward rectification and poor cationic selectivity. Plays a role in prostate cancer cell migration (PubMed:25559186). Isoform 2 and isoform 3 negatively regulate menthol- and cold-induced channel activity by stabilizing the closed state of the channel.

Gene: TRPM8

Poids moléculaire: 128 kDa

ID gène: 79054

UniProt: Q7Z2W7