UIMC1 anticorps (Internal Region)

N° du produit ABIN6265882

Détail du produit anti-UIMC1 anticorps

Antigène: UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))

Épitope: Internal Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UIMC1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: UIMC1 Antibody detects endogenous levels of total UIMC1.

Homologie: Horse,Rabbit,Dog

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human UIMC1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur UIMC1

Antigène: UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))

Autre désignation: UIMC1 (UIMC1 Produits)

Synonymes: anticorps UIMC1, anticorps RAP80, anticorps X2HRIP110, anticorps 9430016E08Rik, anticorps D330018D10Rik, anticorps D630032M02Rik, anticorps RIP110, anticorps Rxrip110, anticorps RGD1307009, anticorps ubiquitin interaction motif containing 1, anticorps UIMC1, anticorps Uimc1

Sujet:

Description: Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref. 37). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

Gene: UIMC1

Poids moléculaire: 80 kDa

ID gène: 51720

UniProt: Q96RL1

Pathways: Réparation de l'ADN, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus