VDAC1 anticorps (C-Term)

N° du produit ABIN6265958

Détail du produit anti-VDAC1 anticorps

Antigène: VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

Épitope: C-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VDAC1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Specificité: VDAC1 Antibody detects endogenous levels of total VDAC1.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human VDAC1, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Références pour anticorps anti-VDAC1 (ABIN6265958)

Zhang, He, Li, Liu, Wang, Zheng, Li: "Emodin targets mitochondrial cyclophilin D to induce apoptosis in HepG2 cells." dans: Biomedicine & pharmacotherapy, Vol. 90, pp. 222-228, (2018) (PubMed).

Li, Chen, Yang, He, He, Xia, Zhang, Xiang: "Single-walled carbon nanohorn aggregates promotes mitochondrial dysfunction-induced apoptosis in hepatoblastoma cells by targeting SIRT3." dans: International journal of oncology, Vol. 53, Issue 3, pp. 1129-1137, (2018) (PubMed).

Détails sur VDAC1

Antigène: VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))

Autre désignation: VDAC1 (VDAC1 Produits)

Synonymes: anticorps vdac1, anticorps VDAC1, anticorps 5076, anticorps ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1, anticorps ATVDAC1, anticorps T22N4.9, anticorps T22N4_9, anticorps voltage dependent anion channel 1, anticorps PORIN, anticorps VDAC-1, anticorps AL033343, anticorps Vdac5, anticorps fa13f11, anticorps wu:fa13f11, anticorps zgc:85830, anticorps voltage-dependent anion channel 1 S homeolog, anticorps voltage-dependent anion channel 1, anticorps voltage dependent anion channel 1, anticorps vdac1.S, anticorps vdac1, anticorps VDAC1, anticorps Vdac1

Sujet:

Description: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules, in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (PubMed:11845315, PubMed:18755977, PubMed:20230784, PubMed:8420959). May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (PubMed:15033708, PubMed:25296756).

Gene: VDAC1

Poids moléculaire: 31kDa

ID gène: 7416

UniProt: P21796