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CDK4 anticorps (Internal Region)

CDK4 Reactivité: Humain, Souris, Rat WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6266370
  • Antigène Voir toutes CDK4 Anticorps
    CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
    Épitope
    • 23
    • 16
    • 16
    • 9
    • 9
    • 9
    • 7
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 120
    • 76
    • 55
    • 19
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 108
    • 34
    • 2
    • 1
    Lapin
    Clonalité
    • 107
    • 37
    Polyclonal
    Conjugué
    • 84
    • 11
    • 11
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp CDK4 est non-conjugé
    Application
    • 122
    • 55
    • 37
    • 31
    • 21
    • 19
    • 16
    • 15
    • 14
    • 13
    • 7
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificité
    CDK4 Antibody detects endogenous levels of total CDK4.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human CDK4, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product CDK4 Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Li, Wang, Yu, Wu, Hu, Wang, Ye: "miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression." dans: Oncology reports, Vol. 37, Issue 1, pp. 241-248, (2017) (PubMed).

    Wang, Ge, Zhang, Chen, Hu, Li, Ye: "Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis." dans: Journal of experimental & clinical cancer research : CR, Vol. 35, pp. 53, (2016) (PubMed).

  • Antigène
    CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
    Autre désignation
    CDK4 (CDK4 Produits)
    Synonymes
    anticorps zgc:153726, anticorps CMM3, anticorps PSK-J3, anticorps Crk3, anticorps 8-6, anticorps CDK4, anticorps CDK4/6, anticorps CG5072, anticorps Cdk4/6, anticorps DmCdk4, anticorps Dmel\\CG5072, anticorps Pk53C, anticorps Pk?7, anticorps cdk, anticorps cdk4, anticorps cdk4/6, anticorps dCdk4, anticorps l(2)05428, anticorps l(2)0671, anticorps l(2)k06503, anticorps l(2)s4639, anticorps l(2)sh0671, anticorps xcdk4, anticorps cyclin-dependent kinase 4, anticorps cyclin dependent kinase 4, anticorps Cyclin-dependent kinase 4, anticorps cyclin-dependent kinase 4 L homeolog, anticorps cdk4, anticorps CDK4, anticorps Cdk4, anticorps cdk4.L
    Sujet

    Description: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

    Gene: CDK4

    Poids moléculaire
    34kDa
    ID gène
    1019
    UniProt
    P11802
    Pathways
    Cycle Cellulaire, Mitotic G1-G1/S Phases, Regulation of Cell Size
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