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TGFB1 anticorps (C-Term)

TGFB1 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6266431
  • Antigène Voir toutes TGFB1 Anticorps
    TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))
    Épitope
    • 55
    • 16
    • 16
    • 15
    • 10
    • 8
    • 8
    • 8
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 167
    • 102
    • 49
    • 23
    • 20
    • 15
    • 12
    • 11
    • 8
    • 7
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 191
    • 44
    • 3
    • 2
    • 1
    • 1
    Lapin
    Clonalité
    • 194
    • 47
    Polyclonal
    Conjugué
    • 97
    • 36
    • 32
    • 13
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 1
    Cet anticorp TGFB1 est non-conjugé
    Application
    • 181
    • 93
    • 68
    • 53
    • 52
    • 42
    • 34
    • 33
    • 31
    • 19
    • 19
    • 11
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    TGF beta1 Antibody detects endogenous levels of total TGF beta1.
    Homologie
    Pig,Bovine,Horse,Sheep,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human TGF beta1, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
  • Indications d'application
    WB: 1:500-1:2000, IHC: 1:50-1:200, IF/ICC 1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Yan, Li, Fan, Du, Ma, Cheng, Li, Zhang, Yu, Wang, Tang, Zheng: "The roles of Toll-like receptor 4 in the pathogenesis of pathogen-associated biliary fibrosis caused by Clonorchis sinensis." dans: Scientific reports, Vol. 7, Issue 1, pp. 3909, (2018) (PubMed).

    Xia, Deng, Zhou, Shao, Yang, Sha, Zou: "Expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction." dans: Transplant immunology, Vol. 48, pp. 18-25, (2018) (PubMed).

    Hui, Dingjie, Yuan, Zhongqiu, Na, Mingjian, Yu, Guangyuan, Xuemin, Shifeng, Yucong, Fang, Summer, Hong: "Silicosis decreases bone mineral density in rats." dans: Toxicology and applied pharmacology, Vol. 348, pp. 117-122, (2018) (PubMed).

    Zhao, Wu, Chen, Ji, Zheng: "TGF-β1 and connexin-43 expression in neurogenic bladder from rats with sacral spinal cord injury." dans: Neurourology and urodynamics, (2018) (PubMed).

    Ai, Liu, Lu, Liang, Sun, Chen, Sun, Li, Liu, Zhang, Liu, Xiao, Jing, Sun, Zhou, Yang: "Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action." dans: Theranostics, Vol. 7, Issue 2, pp. 425-435, (2017) (PubMed).

  • Antigène
    TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))
    Autre désignation
    TGFB1 (TGFB1 Produits)
    Synonymes
    anticorps CED, anticorps DPD1, anticorps LAP, anticorps TGFB, anticorps TGFbeta, anticorps TGF-beta, anticorps TGF-BETA-1, anticorps TGF-beta5, anticorps ced, anticorps dpd1, anticorps lap, anticorps tgf-beta, anticorps tgfb, anticorps tgfb5, anticorps tgfbeta, anticorps TGF-beta1, anticorps TGFbeta1, anticorps Tgfb, anticorps Tgfb-1, anticorps ai39657, anticorps tgfb1, anticorps wu:fb13a07, anticorps xx:ai39657, anticorps TGFB1, anticorps csd, anticorps cdb1, anticorps cdg2, anticorps csd1, anticorps csd2, anticorps csd3, anticorps ebmd, anticorps lcd1, anticorps bigh3, anticorps cdgg1, anticorps betaig-h3, anticorps TGFB4, anticorps transforming growth factor beta 1, anticorps transforming growth factor beta-1, anticorps transforming growth factor beta 1 L homeolog, anticorps transforming growth factor, beta 1, anticorps transforming growth factor, beta 1a, anticorps transforming growth factor beta induced L homeolog, anticorps TGFB1, anticorps Tgfb1, anticorps tgfb1.L, anticorps tgfb1a, anticorps tgfbi.L
    Sujet

    Description: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292).

    Gene: TGFB1

    Poids moléculaire
    45kDa
    ID gène
    7040
    UniProt
    P01137
    Pathways
    EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints
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