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Integrin alpha 4 (ITGA4) (pSer1027) anticorps Primary Antibody

ITGA4 Reactivité: Humain, Souris ELISA, IHC, WB Hôte: Lapin Polyclonal
N° du produit ABIN6271308
$450.00
Plus shipping costs $45.00
local_shipping Destination: Etats-Unis
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  • Antigène
    Épitope
    pSer1027
    Reactivité
    Humain, Souris
    Hôte
    Lapin
    Clonalité
    Polyclonal
    Conjugué
    Inconjugué
    Application
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
    Specificité
    Integrin α4 (Phospho-Ser1027) Antibody detects endogenous levels of Integrin α4 only when phosphorylated at Ser1027
     Réactivité croisée
    Humain, Souris
    Purification
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    Immunogène
    A synthesized peptide derived from human Integrin alpha4 (Phospho-Ser1027)
    Isotype
    IgG
  • Indications d'application
    WB 1:1000-3000, IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C.Stable for 12 months from date of receipt
    Date de péremption
    12 months
  • Antigène
    Autre désignation
    Integrin alpha4 (ITGA4 Antibody Extrait)
    Synonymes
    CD49D, IA4, LOC100219853, integrin subunit alpha 4, integrin alpha 4, integrin subunit alpha 4 S homeolog, ITGA4, Itga4, itga4.S
    Sujet

    Description: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).

    Gene: ITGA4

    Poids moléculaire
    115kDa
    ID gène
    3676
    UniProt
    P13612
    Pathways
    Integrin Complex
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