FZD2 anticorps (Internal Region)

N° du produit ABIN6281808

Détail du produit anti-FZD2 anticorps

Antigène: FZD2 (Frizzled Family Receptor 2 (FZD2))

Épitope: AA 180-260, Internal Region

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Fonction: Frizzled-2 is a protein encoded by the FZD2 gene which is approximately 63,5 kDa. Frizzled-2 is localised to the cell membrane and is involved in CDK-mediated phosphorylation and removal of Cdc6, Wnt signalling pathway and pluripotency and mTOR signalling pathway. It is a receptor for Wnt proteins and is coupled to the beta-catenin canonical signalling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. Frizzled-2 is widely expressed, it is mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. Mutations in the FZD2 gene result in omodysplasia. STJ93141 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Frizzled-2 protein.

Specificité: Frizzled-2 Polyclonal Antibody detects endogenous levels of Frizzled-2 protein.

Attributs du produit: Rabbit polyclonal to Frizzled-2.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human Frizzled-2

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:40000

Commentaires:

Widely expressed. In the adult, mainly found in heart, placenta, skeletal muscle, lung, kidney, pancreas, prostate, testis, ovary and colon. In the fetus, expressed in brain, lung and kidney. Low levels in fetal liver.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur FZD2

Antigène: FZD2 (Frizzled Family Receptor 2 (FZD2))

Autre désignation: Frizzled-2 (FZD2 Produits)

Synonymes: anticorps BG01711, anticorps CG9739, anticorps D-Fz2, anticorps D-fz2, anticorps DFZ2, anticorps DFz-2, anticorps DFz2, anticorps Dfrz2, anticorps Dfz2, anticorps Dfz[[2]], anticorps Dm Fz2, anticorps Dmel\\CG9739, anticorps FZ2, anticorps Fz2, anticorps dFz2, anticorps dfz(2), anticorps dfz2, anticorps dfz2r, anticorps frz2, anticorps fz-2, anticorps fz8, anticorps zfz2, anticorps zg08, anticorps cb383, anticorps wu:fb70g09, anticorps FZD2, anticorps fzE2, anticorps hFz2, anticorps Fz-10, anticorps Fzd10, anticorps cFz-2, anticorps frizzled2, anticorps fz2, anticorps xfz2, anticorps AL033370, anticorps AW456835, anticorps Fz10, anticorps Mfz10, anticorps Mfz10a, anticorps frizzled 2, anticorps frizzled class receptor 2, anticorps frizzled class receptor 2 S homeolog, anticorps fz2, anticorps fzd2, anticorps FZD2, anticorps Fzd2, anticorps fzd2.S

Poids moléculaire: 55 kDa

ID gène: 2535

UniProt: Q14332

Pathways: Signalisation WNT