GSK3 alpha/beta anticorps (pTyr216, pTyr279)

N° du produit ABIN6288285

Détail du produit anti-GSK3 alpha/beta anticorps

Antigène: GSK3 alpha/beta (GSK3a/b) (Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b))

Épitope: AA 220-300, pTyr216, pTyr279

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GSK3 alpha/beta est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Fonction: GSK3α/β is a protein encoded by the GSK3A gene which is approximately 50,9 kDa. GSK3α/β is localised to the mitochondrion. It is involved in the common cytokine receptor gamma-chain family signalling pathways, RET signalling and activation of cAMP-dependent PKA. It is a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also acts as a negative regulator in the hormonal control of glucose homeostasis. GSK3α/β is expressed in the nervous system, liver, eye, pancreas and muscle. Mutations in the GSK3A gene may result in Alzheimer disease. STJ90283 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous GSK3α/β protein which only binds about Y279/216 when Y279/216 is phosphorylated.

Specificité: Phospho-GSK3α/β (Y279/216) Polyclonal Antibody detects endogenous levels of GSK3α/β protein only when phosphorylated at Y279/216.

Attributs du produit: Rabbit polyclonal to Phospho-GSK3α/β (Y279/216).

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human GSK3alpha/beta around the phosphorylation site of Y279/216.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur GSK3 alpha/beta

Antigène: GSK3 alpha/beta (GSK3a/b) (Glycogen Synthase Kinase 3 alpha/beta (GSK3a/b))

Autre désignation: GSK3alpha/beta (GSK3a/b Produits)

Poids moléculaire: 51 kDa

ID gène: 2931

UniProt: P49840