IBTK anticorps

N° du produit ABIN6290521

Détail du produit anti-IBTK anticorps

Antigène: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IBTK est non-conjugé

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogène: Recombinant protein of human IBTK

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000

Commentaires:

Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level), Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines, Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow), Weakly or not expressed in other tissues

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20C. Avoid freeze / thaw cycles.

Détails sur IBTK

Antigène: IBTK (Inhibitor of Bruton Agammaglobulinemia Tyrosine Kinase (IBTK))

Autre désignation: IBTK (IBTK Produits)

Synonymes: anticorps IBTK, anticorps fi40c08, anticorps wu:fi40c08, anticorps DKFZp468J085, anticorps BTBD26, anticorps BTKI, anticorps RP1-93K22.1, anticorps 5430411K16Rik, anticorps AA409502, anticorps mKIAA1417, anticorps inhibitor of Bruton tyrosine kinase, anticorps inhibitor of Bruton agammaglobulinemia tyrosine kinase, anticorps inhibitor of Bruton tyrosine kinase L homeolog, anticorps IBTK, anticorps ibtk, anticorps Ibtk, anticorps ibtk.L

Sujet: Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Poids moléculaire: 150.528 kDa

ID gène: 25998

UniProt: Q9P2D0