Reticulon 3 anticorps
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- Antigène Voir toutes Reticulon 3 (RTN3) Anticorps
- Reticulon 3 (RTN3)
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Reticulon 3 est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogène
- A synthetic peptide of human RTN3
- Isotype
- IgG
- Top Product
- Discover our top product RTN3 Anticorps primaire
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- Indications d'application
- WB 1:500 - 1:2000
- Commentaires
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Isoform 3 is widely expressed, with highest levels in brain, where it is enriched in neuronal cell bodies from gray matter (at protein level), Three times more abundant in macula than in peripheral retina, Isoform 1 is expressed at high levels in brain and at low levels in skeletal muscle, Isoform 2 is only found in melanoma
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20C. Avoid freeze / thaw cycles.
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- Antigène
- Reticulon 3 (RTN3)
- Autre désignation
- RTN3 (RTN3 Produits)
- Synonymes
- anticorps ASYIP, anticorps HAP, anticorps NSPL2, anticorps NSPLII, anticorps RTN3-A1, anticorps MGC56439, anticorps zgc:56439, anticorps zgc:77630, anticorps RTN3, anticorps hap, anticorps asyip, anticorps nspl2, anticorps xrtn3, anticorps nsplii, anticorps rtn3-a1, anticorps RTN3w, anticorps rtn3, anticorps XRTN3, anticorps rtn3-a, anticorps rtn3-b, anticorps reticulon 3, anticorps reticulon 3 L homeolog, anticorps reticulon-3, anticorps reticulon 3 S homeolog, anticorps RTN3, anticorps Rtn3, anticorps rtn3, anticorps rnt3, anticorps rtn3.L, anticorps LOC107131155, anticorps rtn3.S
- Sujet
- This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.
- Poids moléculaire
- 112.611 kDa
- ID gène
- 10313
- UniProt
- O95197
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