C-Type Lectin Domain Family 4, Member M (CLEC4M) anticorps

N° du produit ABIN6291842

Détail du produit

Antigène: C-Type Lectin Domain Family 4, Member M (CLEC4M)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogène: Recombinant protein of human CLEC4M

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000

Commentaires:

Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node, Found in placental endothelium but not in macrophages, Expressed in type II alveolar cells and lung endothelial cells

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20C. Avoid freeze / thaw cycles.

Détail du antigène

Antigène: C-Type Lectin Domain Family 4, Member M (CLEC4M)

Autre désignation: CLEC4M (CLEC4M Produits)

Synonymes: anticorps CD209L, anticorps CD299, anticorps DC-SIGN2, anticorps DC-SIGNR, anticorps DCSIGNR, anticorps HP10347, anticorps L-SIGN, anticorps LSIGN, anticorps CD209B, anticorps C-type lectin domain family 4 member M, anticorps CLEC4M

Sujet: This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835, often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Poids moléculaire: 45.35 kDa

ID gène: 10332

UniProt: Q9H2X3