TYROBP anticorps

N° du produit ABIN6291980

Détail du produit anti-TYROBP anticorps

Antigène: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TYROBP est non-conjugé

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogène: A synthetic peptide of human TYROBP

Isotype: IgG

Information d'application

Indications d'application: WB 1:500 - 1:2000

Commentaires:

Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes, Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen, Also found in bone marrow, lymph nodes, placenta, lung and liver, Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum

Restrictions: For Research Use only

Stockage

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20C. Avoid freeze / thaw cycles.

Détails sur TYROBP

Antigène: TYROBP (TYRO Protein tyrosine Kinase Binding Protein (TYROBP))

Autre désignation: TYROBP (TYROBP Produits)

Synonymes: anticorps TYROBP, anticorps DAP12, anticorps tyrpbp, anticorps Karap, anticorps KARAP, anticorps PLOSL, anticorps Ly83, anticorps dap12, anticorps TYRO protein tyrosine kinase binding protein, anticorps Tyro protein tyrosine kinase binding protein, anticorps TYROBP, anticorps tyrobp, anticorps Tyrobp

Sujet: This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70  kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene.

Poids moléculaire: 12.179 kDa

ID gène: 7305

UniProt: O43914