APPL2 anticorps
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- Antigène Voir toutes APPL2 Anticorps
- APPL2 (Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
- Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp APPL2 est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogène
- Recombinant protein of human APPL2
- Isotype
- IgG
- Top Product
- Discover our top product APPL2 Anticorps primaire
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- Indications d'application
- WB 1:500 - 1:2000
- Commentaires
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High levels in brain, heart, kidney and skeletal muscle
- Restrictions
- For Research Use only
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- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20C. Avoid freeze / thaw cycles.
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- Antigène
- APPL2 (Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))
- Autre désignation
- APPL2 (APPL2 Produits)
- Synonymes
- anticorps RGD1563028, anticorps MGC84621, anticorps dip13b, anticorps APPL2, anticorps DIP13B, anticorps Dip3b, anticorps adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2, anticorps adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog, anticorps adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2, anticorps Appl2, anticorps APPL2, anticorps appl2.L, anticorps appl2
- Sujet
- The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12,22)(q24.1,q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome.
- Poids moléculaire
- 74.493 kDa
- ID gène
- 55198
- UniProt
- Q8NEU8
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