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LDLRAP1 anticorps (N-Term)

LDLRAP1 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN631410
  • Antigène Voir toutes LDLRAP1 Anticorps
    LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))
    Épitope
    • 11
    • 10
    • 8
    • 8
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 56
    • 16
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 51
    • 5
    • 1
    Lapin
    Clonalité
    • 52
    • 5
    Polyclonal
    Conjugué
    • 30
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LDLRAP1 est non-conjugé
    Application
    • 45
    • 33
    • 32
    • 10
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Specificité
    LDLRAP1 antibody was raised against the N terminal of LDLRAP1
    Purification
    Affinity purified
    Immunogène
    LDLRAP1 antibody was raised using the N terminal of LDLRAP1 corresponding to a region with amino acids WTDTRETLLEGMLFSLKYLGMTLVEQPKGEELSAAAIKRIVATAKASGKK
    Top Product
    Discover our top product LDLRAP1 Anticorps primaire
  • Indications d'application
    WB: 1 µg/mL
    Optimal conditions should be determined by the investigator.
    Commentaires

    LDLRAP1 Blocking Peptide, catalog no. 33R-10023, is also available for use as a blocking control in assays to test for specificity of this LDLRAP1 antibody

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of LDLRAP1 antibody in PBS
    Concentration
    Lot specific
    Buffer
    PBS
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • Holla, Strøm, Cameron, Berge, Leren: "A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9." dans: Molecular genetics and metabolism, Vol. 99, Issue 2, pp. 149-56, (2010) (PubMed).

  • Antigène
    LDLRAP1 (Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1))
    Autre désignation
    LDLRAP1 (LDLRAP1 Produits)
    Synonymes
    anticorps ARH, anticorps ARH1, anticorps ARH2, anticorps FHCB1, anticorps FHCB2, anticorps AA691260, anticorps Arh, anticorps Arh1, anticorps RGD1563417, anticorps arh, anticorps arh1, anticorps arh2, anticorps fhcb1, anticorps fhcb2, anticorps xptb, anticorps LDLRAP1, anticorps ldlrap1, anticorps sb:cb50, anticorps zgc:56121, anticorps zgc:158745, anticorps low density lipoprotein receptor adaptor protein 1, anticorps low density lipoprotein receptor adaptor protein 1 L homeolog, anticorps low density lipoprotein receptor adaptor protein 1 S homeolog, anticorps low density lipoprotein receptor adaptor protein 1a, anticorps low density lipoprotein receptor adaptor protein 1b, anticorps LDLRAP1, anticorps Ldlrap1, anticorps ldlrap1, anticorps ldlrap1.L, anticorps ldlrap1.S, anticorps ldlrap1a, anticorps ldlrap1b
    Sujet
    LDLRAP1 is an adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). LDLRAP1 may be required for LDL binding and internalization but not for receptor clustering in coated pits. LDLRAP1 may facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits.
    Poids moléculaire
    34 kDa (MW of target protein)
    Pathways
    Lipid Metabolism
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