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LMX1B anticorps (AA 175-202)

LMX1B Reactivité: Humain, Souris WB, IHC (p) Hôte: Lapin Polyclonal RB21468 unconjugated
N° du produit ABIN652882
  • Antigène Voir toutes LMX1B Anticorps
    LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))
    Épitope
    • 15
    • 6
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 175-202
    Reactivité
    • 37
    • 28
    • 20
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 40
    • 2
    • 1
    Lapin
    Clonalité
    • 42
    • 1
    Polyclonal
    Conjugué
    • 17
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp LMX1B est non-conjugé
    Application
    • 35
    • 17
    • 13
    • 13
    • 6
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    C, X
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This LMX1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 175-202 amino acids from the Central region of human LMX1B.
    Clone
    RB21468
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Doucet-Beaupré, Gilbert, Profes, Chabrat, Pacelli, Giguère, Rioux, Charest, Deng, Laguna, Ericson, Perlmann, Ang, Cicchetti, Parent, Trudeau, Lévesque: "Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 30, pp. E4387-96, (2018) (PubMed).

    Laguna, Schintu, Nobre, Alvarsson, Volakakis, Jacobsen, Gómez-Galán, Sopova, Joodmardi, Yoshitake, Deng, Kehr, Ericson, Svenningsson, Shupliakov, Perlmann: "Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease." dans: Nature neuroscience, Vol. 18, Issue 6, pp. 826-35, (2015) (PubMed).

  • Antigène
    LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))
    Autre désignation
    LMX1B (LMX1B Produits)
    Synonymes
    anticorps LMX1.2, anticorps NPS1, anticorps LMX, anticorps LMX1, anticorps LMX1.1, anticorps lmx1b, anticorps lmx1b.1, anticorps Xlmx1b, anticorps lmx1b.2, anticorps LIM homeobox transcription factor 1 beta, anticorps LIM homeobox transcription factor 1, beta b, anticorps LIM homeobox transcription factor 1, beta, gene 1 S homeolog, anticorps LIM homeobox transcription factor 1, beta a, anticorps LMX1B, anticorps Lmx1b, anticorps lmx1bb, anticorps lmx1b.1.S, anticorps lmx1ba
    Sujet
    LMX1B is required for the normal development of the dopaminergic system. Loss of dopaminergic neurons is associated with one of the most prominent human neurological disorders, Parkinson's disease (PD). Dopaminergic neurons play an important role in the control of multiple brain functions including voluntary movement alongside an array of behavioral processes such as mood, reward, addiction, and stress. Lmx1b is one of several transcription factors involved in the generation of dopaminergic neurons in the brain.
    Poids moléculaire
    44917
    ID gène
    4010
    NCBI Accession
    NP_001167618, NP_002307
    UniProt
    O60663
    Pathways
    Dopaminergic Neurogenesis
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