This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This SLC8A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the Central region of human SLC8A1.
anticorps NCX1, anticorps AI852629, anticorps AV344025, anticorps D930008O12Rik, anticorps Ncx1, anticorps Ncx, anticorps SLC8A1, anticorps ncx1n, anticorps solute carrier family 8 member A1, anticorps solute carrier family 8 (sodium/calcium exchanger), member 1, anticorps solute carrier family 8 (sodium/calcium exchanger), member 1b, anticorps sodium/calcium exchanger 1, anticorps SLC8A1, anticorps Slc8a1, anticorps slc8a1b, anticorps Tsp_07038
Sujet
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) centration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.