KLLN anticorps (C-Term)

N° du produit ABIN655558

Détail du produit anti-KLLN anticorps

Antigène: KLLN (Killin, p53-Regulated DNA Replication Inhibitor (KLLN))

Épitope: AA 136-163, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KLLN est non-conjugé

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This KILLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 136-163 amino acids from the C-terminal region of human KILLIN.

Clone: RB29503

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-KLLN (ABIN655558)

Wang, Roma, Nolley, Abdul-Karim, Peehl, Eng: "Nuclear KLLN expression associates with improved relapse-free survival for prostate carcinoma." dans: Endocrine-related cancer, Vol. 21, Issue 4, pp. 579-86, (2014) (PubMed).

Wang, Yu, He, Romigh, Altemus, Eng: "Activation of AR sensitizes breast carcinomas to NVP-BEZ235's therapeutic effect mediated by PTEN and KLLN upregulation." dans: Molecular cancer therapeutics, Vol. 13, Issue 2, pp. 517-27, (2014) (PubMed).

Wang, He, Yu, Eng: "Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast carcinomas." dans: Human molecular genetics, Vol. 22, Issue 11, pp. 2263-72, (2013) (PubMed).

Détails sur KLLN

Antigène: KLLN (Killin, p53-Regulated DNA Replication Inhibitor (KLLN))

Autre désignation: KILLIN (KLLN Produits)

Synonymes: anticorps CWS4, anticorps KILLIN, anticorps killin, p53-regulated DNA replication inhibitor, anticorps KLLN

Sujet: DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating TP53/p53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double-and single-stranded DNA.

Poids moléculaire: 19958

ID gène: 100144748

NCBI Accession: NP_001119521

UniProt: B2CW77