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P-Glycoprotein anticorps

Reactivité: Souris, Rat WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6568468
  • Antigène Tous les produits P-Glycoprotein
    P-Glycoprotein
    Reactivité
    • 26
    • 10
    • 9
    • 2
    Souris, Rat
    Hôte
    • 21
    • 6
    Lapin
    Clonalité
    • 14
    • 12
    • 1
    Polyclonal
    Conjugué
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp P-Glycoprotein est non-conjugé
    Application
    • 16
    • 7
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Purification
    Affinity purification
    Immunogène
    A synthetic peptide of human P Glycoprotein (NP_000918.2).
    Isotype
    IgG
  • Indications d'application
    WB 1:500-1:2000 IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Avoid freeze / thaw cycles.
  • Antigène
    P-Glycoprotein
    Autre désignation
    P Glycoprotein (P-Glycoprotein Produits)
    Synonymes
    anticorps ABC20, anticorps CD243, anticorps CLCS, anticorps GP170, anticorps MDR1, anticorps P-GP, anticorps PGY1, anticorps Abcb1, anticorps Mdr1a, anticorps ABCB1, anticorps ABCB4, anticorps CMDR1, anticorps xemdr, anticorps ATP binding cassette subfamily B member 1, anticorps ATP binding cassette subfamily B member 1A, anticorps ATP binding cassette subfamily B member 1 L homeolog, anticorps ABCB1, anticorps Abcb1a, anticorps abcb1.L
    Sujet
    The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
    Poids moléculaire

    Observed_MW: Refer to figures

    Calculated_MW: 134kDa/141kDa

    ID gène
    5243
    UniProt
    P08183
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