APEX1 anticorps

N° du produit ABIN6569299

Détail du produit anti-APEX1 anticorps

Antigène: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp APEX1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificité: This antibody ist KO validated.

Purification: Affinity purification

Classe de qualité: KO Validated

Immunogène: Recombinant fusion protein of human APEX1 (NP_542380.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IF 1:50-1:100

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur APEX1

Antigène: APEX1 (Apurinic/Apyrimidinic Endonuclease 1 (APEX1))

Autre désignation: APEX1 (APEX1 Produits)

Synonymes: anticorps apex1, anticorps MGC76280, anticorps MGC79645, anticorps MGC78928, anticorps APE, anticorps APE1, anticorps APEN, anticorps APEX, anticorps APX, anticorps HAP1, anticorps REF1, anticorps Apex, anticorps REF-1, anticorps BAP1, anticorps apex1a, anticorps hm:zehn1532, anticorps wu:fc13d11, anticorps zgc:66204, anticorps Ref-1, anticorps apurinic/apyrimidinic endodeoxyribonuclease 1, anticorps APEX nuclease (multifunctional DNA repair enzyme) 1, anticorps APEX nuclease (multifunctional DNA repair enzyme) 1 L homeolog, anticorps DNA-(apurinic or apyrimidinic site) lyase, anticorps apurinic/apyrimidinic endonuclease 1, anticorps APEX1, anticorps apex1, anticorps apex1.L, anticorps CNG03640, anticorps CNH01280, anticorps nth, anticorps Spirs_4119, anticorps Palpr_0103, anticorps Apex1

Sujet: Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene, all encode the same protein.

Poids moléculaire:

Observed_MW: 40kDa

Calculated_MW: 35kDa

ID gène: 328

UniProt: P27695

Pathways: Réparation de l'ADN, Chromatin Binding, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus