Geminin anticorps

N° du produit ABIN6569833

Détail du produit anti-Geminin anticorps

Antigène: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Geminin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human GMNN (NP_056979.1).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000 IHC 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Geminin

Antigène: Geminin (GMNN) (Geminin, DNA Replication Inhibitor (GMNN))

Autre désignation: GMNN (GMNN Produits)

Synonymes: anticorps CG3183, anticorps Dm Geminin, anticorps Dm geminin, anticorps Dmel\\CG3183, anticorps Gem, anticorps Geminin, anticorps anon-WO0257455.1, anticorps gem, anticorps l(2)k14019, anticorps v(2)k09107, anticorps sb:cb254, anticorps zgc:66217, anticorps GB16871, anticorps GMNN, anticorps geminin, anticorps dyak_GLEANR_833, anticorps DyakGE24654, anticorps GE24654, anticorps LOC100049517, anticorps AW546347, anticorps geminin, DNA replication inhibitor, anticorps CG3183 gene product from transcript CG3183-RA, anticorps geminin, anticorps GE24654 gene product from transcript GE24654-RA, anticorps GMNN, anticorps geminin, anticorps gmnn, anticorps LOC410093, anticorps Dyak\geminin, anticorps Gmnn

Sujet: This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16.

Poids moléculaire:

Observed_MW: 27kDa

Calculated_MW: 23kDa

ID gène: 51053

UniProt: O75496

Pathways: EGFR Signaling Pathway, DNA Replication