SUB1 anticorps

N° du produit ABIN6570210

Détail du produit anti-SUB1 anticorps

Antigène: SUB1 (Activated RNA Polymerase II Transcriptional Coactivator p15 (SUB1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SUB1 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Affinity purification

Immunogène: A synthetic peptide of human PABPC4 (NP_003810.1).

Isotype: IgG

Information d'application

Indications d'application: IHC 1:50-1:200 IF 1:50-1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur SUB1

Antigène: SUB1 (Activated RNA Polymerase II Transcriptional Coactivator p15 (SUB1))

Autre désignation: PC4 (SUB1 Produits)

Synonymes: anticorps P15, anticorps PC4, anticorps p14, anticorps AI842364, anticorps P9, anticorps Pc4, anticorps Rpo2tc1, anticorps SUB1 homolog, transcriptional regulator, anticorps SUB1 homolog (S. cerevisiae), anticorps SUB1, anticorps Sub1

Sujet: Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire:

Observed_MW: 79kDa

Calculated_MW: 69kDa/70kDa/72kDa

ID gène: 8761

UniProt: Q13310