STRA13 anticorps

N° du produit ABIN6572068

Détail du produit anti-STRA13 anticorps

Antigène: STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STRA13 est non-conjugé

Application: Western Blotting (WB)

Purification: Affinity purification

Immunogène: Recombinant fusion protein of human STRA13 (NP_659435.2).

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur STRA13

Antigène: STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))

Autre désignation: STRA13 (STRA13 Produits)

Synonymes: anticorps CENP-X, anticorps CENPX, anticorps D9, anticorps FAAP10, anticorps MHF2, anticorps BHLHB2, anticorps centromere protein X, anticorps CENPX, anticorps Cenpx

Sujet: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.

Poids moléculaire:

Observed_MW: 14kDa

Calculated_MW: 6kDa/7kDa/8kDa

ID gène: 201254

UniProt: A8MT69