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PTPN2 anticorps (C-Term)

PTPN2 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB33304 unconjugated
N° du produit ABIN657234
  • Antigène Voir toutes PTPN2 Anticorps
    PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
    Épitope
    • 7
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 329-358, C-Term
    Reactivité
    • 40
    • 17
    • 17
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    Humain
    Hôte
    • 38
    • 2
    Lapin
    Clonalité
    • 40
    Polyclonal
    Conjugué
    • 23
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PTPN2 est non-conjugé
    Application
    • 31
    • 20
    • 16
    • 6
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This PTPN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-358 amino acids from the C-terminal region of human PTPN2.
    Clone
    RB33304
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PTPN2 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Date de péremption
    6 months
  • Aradi, Kato, Filkova, Karouzakis, Klein, Scharl, Kolling, Michel, Gay, Buzas, Gay, Jüngel: "Protein Tyrosine Phosphatase Nonreceptor Type 2 (PTPN2), an Important Regulator of IL-6 Production in Rheumatoid Arthritis Synovial Fibroblasts." dans: Arthritis & rheumatology (Hoboken, N.J.), (2015) (PubMed).

  • Antigène
    PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
    Autre désignation
    PTPN2 (PTPN2 Produits)
    Synonymes
    anticorps PTN2, anticorps PTPT, anticorps TC-PTP, anticorps TCELLPTP, anticorps TCPTP, anticorps AI325124, anticorps Ptpt, anticorps PTP-1B, anticorps cb806, anticorps ptpn2, anticorps ptpn2l, anticorps wu:fc10h07, anticorps zgc:55339, anticorps zgc:76973, anticorps hm:zeh1546, anticorps zgc:63623, anticorps ptn2, anticorps ptpt, anticorps tc-ptp, anticorps tcellptp, anticorps tcptp, anticorps protein tyrosine phosphatase, non-receptor type 2, anticorps protein tyrosine phosphatase, non-receptor type 2 S homeolog, anticorps protein tyrosine phosphatase, non-receptor type 2, b, anticorps protein tyrosine phosphatase, non-receptor type 2, a, anticorps protein tyrosine phosphatase, non-receptor type 2 L homeolog, anticorps PTPN2, anticorps Ptpn2, anticorps ptpn2.S, anticorps ptpn2b, anticorps ptpn2a, anticorps ptpn2.L
    Sujet
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported. [provided by RefSeq].
    Poids moléculaire
    48473
    NCBI Accession
    NP_002819, NP_536347, NP_536348
    UniProt
    P17706
    Pathways
    EGFR Signaling Pathway, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling
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