TRAF3 anticorps (TNF Receptor-Associated Factor 3) (C-Term) Primary Antibody
- Cet anticorp TRAF3 est non-conjugé
- ELISA, Fluorescence Microscopy (FM), Western Blotting (WB)
- Réactivité croisée
- Humain, Souris
- Réactivité croisée (Details)
- Cross reactivity with TRAF3 from other sources has not been determined.
- Anti-TRAF3 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography.
Immunogen: Anti-TRAF3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 16 amino acid synthetic peptide from near the C-terminus of human TRAF3.
Immunogen Type: Peptide
- Indications d'application
Application Note: Anti-TRAF3 Antibody has been tested for use in ELISA, Western Blotting and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 64 kDa in Western Blots of specific cell lysates and tissues.
ELISA Dilution: 1:10,000-1:20,000
Western Blot Dilution: 1-2 μg/mL
IF Microscopy Dilution: 2 μg/mL
- For Research Use only
Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- RT,4 °C,-20 °C
- Stockage commentaire
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
- Autre désignation
- TRAF3 (TRAF3 Antibody Extrait)
Synonyms: TRAF3 Antibody, CAP1, LAP1, CAP-1, CRAF1, IIAE5, CD40bp, CAP1, TNF receptor-associated factor 3
Background: Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily. TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1. Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-kB. Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbetaR.
Gene Name: TRAF3
- ID gène
- NCBI Accession
- Signalisation NF-kappaB, Apoptose, Signalisation TLR, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades