KCNMB2 anticorps (C-Term, N-Term)

N° du produit ABIN6657685

Détail du produit anti-KCNMB2 anticorps

Antigène: KCNMB2 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 2 (KCNMB2))

Épitope: C-Term, N-Term

Reactivité: Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KCNMB2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: Anti-BK channel BETA2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with BK channel BETA2 from human, mouse, and rat based on 100% homology with the immunizing sequence. Detects endogenous and exogenous hsp22 in monomeric, dimeric and tetrameric forms in WB. Does not cross react with alpha crystallin. Cross-reactivity with BK channel BETA2 from other sources has not been determined. Ion Channels research.

Immunogène:

Immunogen: BK channel BETA2 Antibody was produced in mice by repeated immunizations with a fusion protein N-terminus and C-terminus regions of mouse BKBeta2.

Immunogen Type: Recombinant Protein

Clone: S53-32

Isotype: IgG1

Information d'application

Indications d'application:

Immunohistochemistry Dilution: User Optimized

Application Note: Anti-BK channel Beta3 Antibody is suitable for use in WB, IP, and IHC. Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: User Optimized

Western Blot Dilution: 1:2000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Stock: RT,4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Détails sur KCNMB2

Antigène: KCNMB2 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 2 (KCNMB2))

Autre désignation: BK channel BETA2 (KCNMB2 Produits)

Synonymes: anticorps KCNMB3, anticorps zgc:101842, anticorps KCNMB2, anticorps 2700049B16Rik, anticorps 3110031N04Rik, anticorps Kcmb2, anticorps potassium calcium-activated channel subfamily M regulatory beta subunit 2, anticorps potassium large conductance calcium-activated channel, subfamily M, beta member 2, anticorps KCNMB2, anticorps kcnmb2, anticorps Kcnmb2

Sujet:

Synonyms: KCNMB2, Calcium-activated potassium channel subunit beta-2, BK channel subunit beta-2, BKbeta2, Calcium-activated potassium channel, subfamily M subunit beta-2, Charybdotoxin receptor subunit beta-2, K(VCA)beta-2, Maxi K channel subunit beta-2, Slo-beta-2

Background: BK channels contribute to electrical impulses, proper signal transmission of information and regulation of neurotransmitter release. A gain of function mutation in the pore-forming alpha subunit of the BK channel was linked to human neurological diseases. Findings suggest that the distribution of the beta subunits in the brain can modulate the BK channels to contribute to the pathophysiology of epilepsy and dyskinesia. This has major implications on other physiological processes in tissues other than the brain.

Gene Name: Kcnmb2

ID gène: 72413

NCBI Accession: NP_082507

UniProt: Q9CZM9