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SCN1A anticorps (C-Term)

SCN1A Reactivité: Rat IHC, WB, IP, FM Hôte: Souris Monoclonal S74-71 unconjugated
N° du produit ABIN6658122
  • Antigène Voir toutes SCN1A Anticorps
    SCN1A (Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A))
    Épitope
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 26
    • 17
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 24
    • 2
    • 1
    Souris
    Clonalité
    • 25
    • 2
    Monoclonal
    Conjugué
    • 16
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SCN1A est non-conjugé
    Application
    • 11
    • 10
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Fluorescence Microscopy (FM)
     Réactivité croisée
    Humain, Souris, Rat (Rattus)
    Purification
    Anti-Nav1.1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Nav1.1 from Mouse, Human, and Rat based on 100% homology with the immunizing sequence. No cross reactivity against Nav1.2, Nav1.3 and Nav1.6. Cross-reactivity with Nav1.1 from other sources has not been determined. Ion Channels research.
    Immunogène

    Immunogen: Nav1.1 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to the cytoplasmic C-terminus region of rat Nav1.1.

    Immunogen Type: Recombinant Protein

    Clone
    S74-71
    Isotype
    IgG1
    Top Product
    Discover our top product SCN1A Anticorps primaire
  • Indications d'application

    Immunohistochemistry Dilution: 0.1-1.0 μg/mL

    Application Note: Anti-Nav1.1 Antibody is suitable for use in WB, IP, and IHC. Expect a band approximately ~220 kDa on specific lysates. Epitope mapped within amino acids 690-715. Specific conditions for reactivity should be optimized by the end user.

    Immunoprecipitation Dilution: User Optimized

    Western Blot Dilution: 1 μg/mL

    IF Microscopy Dilution: 1.0-10 μg/mL

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: 50 % (v/v) Glycerol

    Stock
    RT,4 °C,-20 °C
    Stockage commentaire
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
  • Antigène
    SCN1A (Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A))
    Autre désignation
    Nav1.1 (SCN1A Produits)
    Synonymes
    anticorps SCN9A, anticorps SCN1A, anticorps B230332M13, anticorps Nav1.1, anticorps EIEE6, anticorps FEB3, anticorps FEB3A, anticorps FHM3, anticorps GEFSP2, anticorps HBSCI, anticorps NAC1, anticorps SCN1, anticorps SMEI, anticorps sodium voltage-gated channel alpha subunit 1, anticorps sodium voltage-gated channel alpha subunit 9, anticorps sodium channel, voltage-gated, type I, alpha, anticorps SCN1A, anticorps SCN9A, anticorps Scn1a
    Sujet

    Synonyms: FEB3, Scn1a, GEFSP2, HBSCI, SCN1, Sodium channel 3

    Background: Voltage gated sodium channels initiate action potentials in neurons. Nav1.1 is abundant in the adult brain, and primarily localized in cell bodies. Mutations in the Nav1.1 channels cause generalized epilepsy with febrile seizures plus (GEFS+). Studies show that Nav1.1 channels also play a crucial role in the excitability of cerebellar Purkinje neurons, with major contributions to peak, persistent and resurgent forms of sodium current and to sustained action potential firing.

    Gene Name: Scn1a

    ID gène
    20265
    NCBI Accession
    NP_061203
    UniProt
    Q62206
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