SCN2A anticorps (C-Term)

N° du produit ABIN6658123

Détail du produit anti-SCN2A anticorps

Antigène: SCN2A (Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Épitope: C-Term

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SCN2A est non-conjugé

Application: Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Fluorescence Microscopy (FM)

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: Anti-Nav1.2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Nav1.2 from Mouse, Human, and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with Nav1.2 from other sources has not been determined. Ion Channels research.

Immunogène:

Immunogen: Nav1.2 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to the cytoplasmic C-terminus region of rat Nav1.2.

Immunogen Type: Recombinant Protein

Clone: S69-3

Isotype: IgG2a

Information d'application

Indications d'application:

Immunohistochemistry Dilution: 0.1-1.0 μg/mL

Application Note: Anti-Nav1.2 Antibody is suitable for use in WB, IP, and IHC. Expect a band approximately ~250 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: User Optimized

Western Blot Dilution: 1 μg/mL

IF Microscopy Dilution: 1.0-10 μg/mL

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

0.09 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: RT,4 °C,-20 °C

Stockage commentaire: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Détails sur SCN2A

Antigène: SCN2A (Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Autre désignation: Nav1.2 (SCN2A Produits)

Synonymes: anticorps SCN2A2, anticorps 6430408L10, anticorps A230052E19Rik, anticorps Nav1.2, anticorps Scn2a, anticorps NachII, anticorps RII/RIIA, anticorps RNSCPIIR, anticorps SCN, anticorps SCN2A, anticorps Scn2a2, anticorps ScpII, anticorps BFIC3, anticorps BFIS3, anticorps BFNIS, anticorps EIEE11, anticorps HBA, anticorps HBSCI, anticorps HBSCII, anticorps NAC2, anticorps Na(v)1.2, anticorps SCN2A1, anticorps sodium voltage-gated channel alpha subunit 2, anticorps sodium channel protein type 2 subunit alpha, anticorps sodium channel, voltage-gated, type II, alpha, anticorps sodium channel, voltage-gated, type II, alpha subunit, anticorps SCN2A, anticorps LOC100217927, anticorps LOC100389294, anticorps LOC100484218, anticorps Scn2a, anticorps LOC478773

Sujet:

Synonyms: SCN, SCN2A, ScpII, NachII, Nav1.2, Scn2a2, RII/RIIA, RNSCPIIR, Scn2a1, Sodium channel protein type 2 subunit alpha, Sodium channel protein brain II subunit alpha, Sodium channel protein type II subunit alpha, Voltage-gated Sodium channel subunit alpha Nav1.2

Background: Nav1.2 is a protein that in humans is encoded by the SCN2A gene. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. Neuronal Nav1.2 channels are therapeutic targets in seizure, pain and stroke.

Gene Name: Scn2a

ID gène: 24766

NCBI Accession: NP_036779

UniProt: P04775