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GABRA5 anticorps (Cytoplasmic Loop)

GABRA5 Reactivité: Rat WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6658274
  • Antigène Voir toutes GABRA5 Anticorps
    GABRA5 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 5 (GABRA5))
    Épitope
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cytoplasmic Loop
    Reactivité
    • 20
    • 15
    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Rat
    Hôte
    • 20
    • 3
    Lapin
    Clonalité
    • 12
    • 11
    Polyclonal
    Conjugué
    • 16
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GABRA5 est non-conjugé
    Application
    • 15
    • 7
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Purification
    Anti-GABA(A) Receptor alpha 5 Antibody is directed against rat GABA(A) Receptor alpha 5. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Reactivity is expected from the following species based on 100% sequence homology: bovine, chicken, canine, human, mouse, non-human primate, and zebra fish.
    Immunogène

    Immunogen: Anti-GABA(A) Receptor alpha 5 Antibody was produced by repeated immunizations with recombinant fusion proteins from the cytoplasmic loop of the alpha 5 subunit.

    Immunogen Type: Recombinant Protein

    Isotype
    IgG
    Top Product
    Discover our top product GABRA5 Anticorps primaire
  • Indications d'application

    Application Note: Anti-GABA(A) Receptor alpha 5 (Rabbit) antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 55 kDa in size corresponding to the alpha 5 subunit of the GABA(A) receptor in Western Blots of rat brain extracts.

    Western Blot Dilution: 1:1000

    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer

    Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

    Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

    Stock
    4 °C,-20 °C
    Stockage commentaire
    Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
  • Antigène
    GABRA5 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 5 (GABRA5))
    Autre désignation
    GABA(A) Receptor alpha 5 (GABRA5 Produits)
    Synonymes
    anticorps GABRA5, anticorps si:dkey-93p24.1, anticorps A230018I05Rik, anticorps gamma-aminobutyric acid type A receptor alpha5 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, alpha 5, anticorps gamma-aminobutyric acid type A receptor alpha 5 subunit, anticorps gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5, anticorps gamma-aminobutyric acid receptor subunit alpha-5, anticorps GABRA5, anticorps gabra5, anticorps Gabra5, anticorps LOC100653497
    Sujet

    Synonyms: Gamma-aminobutyric acid receptor subunit alpha-5, GABA(A) receptor subunit alpha-5, Gabra5

    Background: Anti-GABA(A) Receptor alpha 5 Antibody detects GABA(A) Receptor alpha 4. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. GABA(A) receptor alpha 5 antibody is ideal for investigators involved in Neuroscience.

    Gene Name: GABRA5

    ID gène
    29707
    NCBI Accession
    NP_058991
    UniProt
    P19969
    Pathways
    Sensory Perception of Sound, Synaptic Membrane
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