C-JUN anticorps (Jun Proto-Oncogene)

Details for Product anti-JUN Antibody No. ABIN6673958
Antigène
  • AP-1
  • AP1
  • c-Jun
  • fj36h07
  • wu:fj36h07
  • zgc:65863
  • Junc
  • c-jun
  • CG2275
  • D-Jun
  • D-jun
  • D-jun/Jra
  • DJUN
  • DJun
  • Djun
  • Dmel\\CG2275
  • JRA
  • JUN
  • Jun
  • V
  • cJun
  • d-JRA
  • d-Jun
  • d-jun
  • dAP-1
  • dJRA
  • dJUN
  • dJra
  • dJun
  • djun
  • dm-Jun
  • jra
  • jun
  • l(2)46Ef
  • l(2)IA109
  • l(2R)IA109
  • Jun proto-oncogene, AP-1 transcription factor subunit
  • jun proto-oncogene S homeolog
  • jun proto-oncogene
  • Jun-related antigen
  • jun proto-oncogene L homeolog
  • JUN
  • Jun
  • jun.S
  • jun
  • Jra
  • jun.L
Reactivité
Humain, Souris, Rat (Rattus)
1044
626
549
66
54
40
39
36
34
31
21
17
10
7
5
4
4
1
1
1
1
Hôte
Lapin
962
104
2
1
1
Clonalité
Polyclonal
Conjugué
Cet anticorp C-JUN est non-conjugé
38
23
23
23
23
23
23
21
21
13
13
13
7
7
7
7
7
4
3
3
3
3
3
3
3
3
3
3
3
Application
Western Blotting (WB)
782
484
266
150
105
97
94
75
27
17
15
10
9
9
9
6
3
2
1
1
Options
Immunogène Recombinant protein of human JUN
Isotype IgG
Purification Affinity purification
Plasmids, Primers & others Plasmids, Primers & others C-JUN products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation JUN (JUN Antibody Extrait)
Sujet C-Jun is a member of the Jun Family containing c-Jun, JunB and JunD, and is a component of the transcription factor AP-1 (activator protein-1). AP-1 is composed of dimers of Fos, Jun and ATF family members and binds to and activates transcription at TRE/AP-1 elements (reviewed in 1). Extracellular signals including growth factors, chemokines and stress activate AP-1-dependent transcription. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK (reviewed in 2). Knock-out studies in mice have shown that c-Jun is essential for embryogenesis , and subsequent studies have demonstrated roles for c-Jun in various tissues and developmental processes including axon regeneration , liver regeneration and T cell development. AP-1 regulated genes exert diverse biological functions including cell proliferation, differentiation, and apoptosis, as well as transformation, invasion and metastasis, depending on cell type and context. Other target genes regulate survival as well as hypoxia and angiogenesis. c-Jun has emerged as a promising therapeutic target for cancer, vascular remodeling, acute inflammation, as well as rheumatoid arthritis.
Synonyms: JUN, AP-1, AP1, c-Jun
ID gène 3725
UniProt P05412
Pathways Signalisation MAPK, Signalisation RTK, Signalisation WNT, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Autophagy, Signaling of Hepatocyte Growth Factor Receptor
Indications d'application Recommended dilutions: WB: 1:500-1:2000
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Agent conservateur Sodium azide
Précaution d'utilisation This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid freeze / thaw cycles
Stock -20 °C,-80 °C
Stockage commentaire

Storage: -20 °C/-80 °C

Images (Fournisseur)
Immunofluorescence (IF) image for anti-Jun Proto-Oncogene (JUN) antibody (ABIN6673958) Immunofluorescence analysis of A549 cell using Jun antibody. Blue: DAPI for nuclear s...
Western Blotting (WB) image for anti-Jun Proto-Oncogene (JUN) antibody (ABIN6673958) Western blot analysis of extracts of PC3 cells, using c-Jun antibody.
Immunohistochemistry (IHC) image for anti-Jun Proto-Oncogene (JUN) antibody (ABIN6673958) anti-Jun Proto-Oncogene (JUN) antibody (Image 3)
Produit citée dans: Wang, Wang, Lou, Ma, Li, Zhang, Wang, Li, Awais, Cao, She, Fu, Cui: "IP-10 Promotes Blood-Brain Barrier Damage by Inducing Tumor Necrosis Factor Alpha Production in Japanese Encephalitis." dans: Frontiers in immunology, Vol. 9, pp. 1148, 2018 (PubMed). Méthode utilisée: Western Blotting (WB)

He, Zhao, Anees, Li, Ashraf, Chen, Song, Chen, Cao, Ye: "p21-Activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus-Mediated Inflammation in Astrocytes." dans: Frontiers in cellular and infection microbiology, Vol. 7, pp. 271, 2018 (PubMed). Méthode utilisée: Western Blotting (WB)

Ye, Zhang, He, Zhu, Zhou, Chen, Ashraf, Wei, Liu, Fu, Chen, Cao: "Quantitative phosphoproteomic analysis identifies the critical role of JNK1 in neuroinflammation induced by Japanese encephalitis virus." dans: Science signaling, Vol. 9, Issue 448, pp. ra98, 2017 (PubMed). Méthode utilisée: Western Blotting (WB)

Cao, Sun, Zhang, Guo, Xie, Li, Wu, Liu: "The long intergenic noncoding RNA UFC1, a target of MicroRNA 34a, interacts with the mRNA stabilizing protein HuR to increase levels of β-catenin in HCC cells." dans: Gastroenterology, Vol. 148, Issue 2, pp. 415-26.e18, 2015 (PubMed). Méthode utilisée: Western Blotting (WB)

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