SLC22A17 anticorps (AA 475-538)

N° du produit ABIN668691

Détail du produit anti-SLC22A17 anticorps

Antigène: SLC22A17 (Solute Carrier Family 22 (Organic Cation Transporter), Member 17 (SLC22A17))

Épitope: AA 475-538

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC22A17 est non-conjugé

Application: ELISA, Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Réactivité croisée: Humain, Rat

Homologie: Mouse,Dog,Cow,Pig

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human SLC22A17

Isotype: IgG

Information d'application

Indications d'application: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Date de péremption: 12 months

Références pour anticorps anti-SLC22A17 (ABIN668691)

Wu, Du, Lok, Lo, Xing: "Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms." dans: Journal of neurochemistry, (2015) (PubMed).

Cui, Xu, Shen, Tao, Gao, Lv, Du, Fang, Li: "NGALR is overexpressed and regulated by hypomethylation in esophageal squamous cell carcinoma." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 23, pp. 7674-81, (2009) (PubMed).

Détails sur SLC22A17

Antigène: SLC22A17 (Solute Carrier Family 22 (Organic Cation Transporter), Member 17 (SLC22A17))

Autre désignation: Slc22A17 (SLC22A17 Produits)

Synonymes: anticorps 1700094C23Rik, anticorps 24p3R, anticorps AU041908, anticorps AW555662, anticorps BOIT, anticorps Boct, anticorps mBOCT, anticorps BOCT, anticorps NGALR, anticorps NGALR2, anticorps NGALR3, anticorps hBOIT, anticorps rBOCT, anticorps solute carrier family 22 member 17, anticorps solute carrier family 22 (organic cation transporter), member 17, anticorps solute carrier family 22, member 17, anticorps SLC22A17, anticorps Slc22a17

Sujet:

Synonyms: BOCT, BOIT, 24p3R, NGALR, hBOIT, NGALR2, NGALR3, Solute carrier family 22 member 17, 24p3 receptor, Brain-type organic cation transporter, Lipocalin-2 receptor, Neutrophil gelatinase-associated lipocalin receptor, SLC22A17

Background: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).

ID gène: 51310

UniProt: Q8WUG5

Pathways: Transition Metal Ion Homeostasis